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How to use AI to analyze responses from clinical trial participants survey about barriers to participation

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Adam Sabla

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Aug 23, 2025

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This article will give you tips on how to analyze responses/data from Clinical Trial Participants survey about Barriers To Participation using AI and survey analysis tools built for qualitative and quantitative research.

Choosing the right tools for analyzing survey responses

The right approach to analyzing survey responses comes down to the data you’ve collected and its structure. You need different tools for quantitative and qualitative data—and each method delivers unique value.

  • Quantitative data: If you’re dealing with numbers—like how many people cited a particular barrier or selected a certain option—Excel or Google Sheets will do the job. You can quickly tally up responses and spot trends in participation rates or barrier frequency.

  • Qualitative data: When your survey contains open-ended questions or branching follow-ups (e.g., “What made you hesitant to join a trial?”), the volume and diversity of responses get overwhelming, fast. Sifting through dozens or hundreds of conversations is impossible by hand. These types of responses need AI analysis to surface themes, highlight common pain points, and summarize sentiment across participants.

There are two approaches for tooling when dealing with qualitative responses:

ChatGPT or similar GPT tool for AI analysis

You can export your open-ended survey responses and paste them into ChatGPT (or another GPT-based tool) for analysis. This lets you chat about your data and ask the AI direct questions, such as “What are the most common reasons people refused to participate?” or “Summarize key motivators among rural respondents.”


However, managing your data this way isn’t very convenient. Every time you want to refine your question or dig deeper, you have to copy and reformat the data, which creates a messy back-and-forth. Larger datasets quickly hit context limits, so you may have to chunk your data—and ChatGPT doesn’t give you tools for filtering participants, tracking follow-ups, or organizing your insights.

All-in-one tool like Specific

Specific was designed to make the end-to-end survey workflow effortless. It lets you create your Clinical Trial Participants survey about Barriers To Participation, collect structured and conversational feedback, and analyze results with AI—all in one place.

What makes Specific unique: It asks smart, context-aware AI follow-up questions while collecting responses, so you always get extra detail and clarity—no generic “please explain” boxes. This improves the quality of the responses and unearths pain points you’d miss with static forms. For more context, see how AI followup questions work.

When analyzing, Specific uses AI to instantly summarize what participants said, extract core themes, and organize barriers, motivators, and challenges—without spreadsheets or manual coding. You can also chat directly with AI about the results, just like you would with ChatGPT, but with added features for filtering, segmenting, and managing your data context.

You never waste time wrangling exports—and you always know you’re seeing insights grounded in the way your survey was structured.


Useful prompts that you can use to analyze Clinical Trial Participants survey data about barriers to participation

When you’re ready to dig into open-ended responses from Clinical Trial Participants, the prompts you use with your AI analysis tool matter. Here are powerful, field-tested prompts for surfacing actionable insights about Barriers To Participation.


Prompt for core ideas: Great for extracting themes and key issues from a large collection of responses. This is built into Specific, but works in ChatGPT as well:

Your task is to extract core ideas in bold (4-5 words per core idea) + up to 2 sentence long explainer.

Output requirements:

- Avoid unnecessary details

- Specify how many people mentioned specific core idea (use numbers, not words), most mentioned on top

- no suggestions

- no indications

Example output:

1. **Core idea text:** explainer text

2. **Core idea text:** explainer text

3. **Core idea text:** explainer text

Tip: AI always performs better with context. Before running your prompt, describe your survey briefly so the AI understands the scenario, e.g.:

This data comes from a survey of clinical trial participants regarding barriers to participation in research studies. The goal is to uncover key reasons why people hesitate or drop out, so that recruitment and retention strategies can be improved. Please analyze accordingly.

When you want to go deep on a specific theme, try: “Tell me more about [core idea, e.g. ‘fear of side effects’]”

Prompt for specific topic: To quickly check if and how a barrier was mentioned, ask the AI:

Did anyone talk about [topic, e.g. “transportation barriers”]? Include quotes.

Prompt for personas: Useful if you want to segment participants by their background or motivators:

Based on the survey responses, identify and describe a list of distinct personas—similar to how "personas" are used in product management. For each persona, summarize their key characteristics, motivations, goals, and any relevant quotes or patterns observed in the conversations.

Prompt for pain points and challenges: To see what’s making trial participation hard, try:

Analyze the survey responses and list the most common pain points, frustrations, or challenges mentioned. Summarize each, and note any patterns or frequency of occurrence.

Prompt for motivators & drivers: If you want to know what helps people decide to participate:

From the survey conversations, extract the primary motivations, desires, or reasons participants express for their behaviors or choices. Group similar motivations together and provide supporting evidence from the data.

Prompt for sentiment analysis: To get a read on how people feel about trials overall:

Assess the overall sentiment expressed in the survey responses (e.g., positive, negative, neutral). Highlight key phrases or feedback that contribute to each sentiment category.

Prompt for unmet needs & opportunities: To spot where you could do better:

Examine the survey responses to uncover any unmet needs, gaps, or opportunities for improvement as highlighted by respondents.

Experiment with these prompts and fine-tune based on what you want to learn—especially when there are such deep, diverse barriers at play. Clinical trials lose enormous value due to poor participation, with only about 20% recruiting participants on time and 18% failing due to recruitment shortfalls [1][2]. Getting the analysis right is worth the investment.

For more ideas on survey and analysis question design, see questions for clinical trial participants surveys.

How Specific analyzes qualitative data by question type

The strength of AI-driven analysis is in how it contextualizes answers based on the question format. Here’s how Specific handles each commonly used type:


  • Open-ended questions with or without follow-ups: Specific summarizes all the responses and the resulting follow-ups for the given question—capturing nuance and different angles on each barrier or experience.

  • Choices with follow-ups: For every answer option (e.g., “cost”, “distance”, “side effects”), the tool creates separate summaries of all responses to the follow-ups linked to that choice. You immediately see why someone chose one barrier and how they describe the details.

  • NPS questions: Each NPS segment (detractors, passives, promoters) gets its own summary of responses about why they rated the experience as they did and what held them back or moved them forward.

You can achieve the same outcome using ChatGPT by filtering responses and copying separate datasets into the chat, but it’s much more labor-intensive and less error-proof.


For more on survey analysis powered by AI, see our detailed guide on AI survey response analysis.

How to manage AI context size limits for large survey datasets

AIs like GPT have a context (token) limit: only so much data can be sent for analysis at once. Qualitative datasets from Barriers To Participation surveys often go beyond those limits—especially when you want every anecdote, not just a summary.


There are two main solutions:

  • Filtering: Filter conversations based on user replies. With Specific, you can zero in on just those Clinical Trial Participants who mentioned “childcare barriers” or “financial hurdles,” for example. That means only the most relevant responses get analyzed, keeping within the context boundary.

  • Cropping: Crop questions for AI analysis. Instead of sending the whole survey, choose specific questions or sections for your query—allowing deep dives without overloading the AI.

Both strategies let you analyze more data accurately and efficiently. Specific automates these steps, but if using ChatGPT directly, you’ll need to prepare filtered or cropped data manually.


For survey design tips that reduce context overload, check out how to create effective Clinical Trial Participants surveys.

Collaborative features for analyzing Clinical Trial Participants survey responses

Collaboration is tough when everyone works from different spreadsheets or emails long copy-paste chains. With complex Clinical Trial Participants Barriers To Participation surveys, teams need a way to share analysis, validate findings, and explore divergent themes together in real time.

Specific solves this pain by letting you analyze survey data just by chatting with AI—no dashboards or exports needed. You and your colleagues can open multiple analytics chats, each focused on a different subtopic: you might have one chat digging into financial barriers, another on participant motivations, and a third on urban vs. rural gaps. Each chat tracks who created it and which filters were applied, preventing overlap and confusion.

Direct visibility into collaboration: Every message in an AI chat thread shows the sender’s avatar, so it’s clear who asked what and why. This level of visibility keeps your team aligned, cuts down on duplicate work, and speeds consensus on urgent recruitment challenges—critical, since nearly 80% of clinical trials face delays due to participant enrollment challenges [1].

For a closer look at collaborative survey analysis and chat-based workflows, see this breakdown of collaborative features.

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Sources

  1. wifitalents.com. Clinical trial participation statistics, including recruitment challenges and barriers.

  2. zipdo.co. Clinical trial participation data: delays, attrition, and reasons for nonparticipation.

Adam Sabla - Image Avatar

Adam Sabla

Adam Sabla is an entrepreneur with experience building startups that serve over 1M customers, including Disney, Netflix, and BBC, with a strong passion for automation.

Adam Sabla

Adam Sabla is an entrepreneur with experience building startups that serve over 1M customers, including Disney, Netflix, and BBC, with a strong passion for automation.

Adam Sabla

Adam Sabla is an entrepreneur with experience building startups that serve over 1M customers, including Disney, Netflix, and BBC, with a strong passion for automation.